Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia.

Abstract

Certain types of chromosomal abnormalities have been shown to exert strong independent influence on treatment outcome in acute lymphoblastic leukemia (ALL). To identify the changes most closely associated with prognosis, we analyzed the completely banded blast cell karyotypes of 161 children with this disease. One hundred twenty-five cases had one or more… (More)

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