Chromosomal translocations induced at specified loci in human stem cells.

Abstract

The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies. Chromosomal translocations are hallmarks of several tumor types where they are thought to have arisen in stem or precursor cells. Although approaches exist to study factors involved in translocation… (More)
DOI: 10.1073/pnas.0902076106

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