Chromosomal translocations in sarcomas: prospects for therapy.

@article{Tomescu2001ChromosomalTI,
  title={Chromosomal translocations in sarcomas: prospects for therapy.},
  author={Oana A. Tomescu and F. G. Barr},
  journal={Trends in molecular medicine},
  year={2001},
  volume={7 12},
  pages={554-9}
}
In the past two decades, cytogenetic and molecular genetic investigations have revealed that sarcomas are frequently characterized by specific chromosomal translocations, often involving genes encoding transcription factors. These translocations result in the expression of chimeric oncoproteins that contain functional domains contributed by each of the parental genes. Functioning as deregulated transcription and signaling factors, these novel proteins contribute to the malignant phenotype of… CONTINUE READING

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