Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

  title={Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.},
  author={Bihui H. Ye and Seeta R Chaganti and Chiao Chia Chang and Hengyao Niu and P. Poggi – Corradini and Raju S.K. Chaganti and Riccardo Dalla-Favera},
  journal={The EMBO journal},
  volume={14 24},
The BCL6 gene codes for a zinc-finger transcription factor and is involved in chromosomal rearrangements in 30-40% of diffuse large-cell lymphoma (DLCL). These rearrangements cluster within the 5' regulatory region of BCL6 spanning its first non-coding exon. To determine the functional consequences of these alterations, we have analyzed the structure of the rearranged BCL6 alleles and their corresponding RNA and protein species in two DLCL biopsies and one tumor cell line which carried the t(3… CONTINUE READING


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