Chromosomal translocation t(1;9)(q24;q34) in acute lymphoblastic leukemia patient involving the ABL1 gene.


The cellular ABL1 gene located at 9q34 is the human homoogue of the viral ABL1 oncogene coding for a protein that has yrosine kinase activity. The structure of the ABL protein and the echanisms of leukemogenic transformation induced by oncoenic forms of ABL have been the object of extensive studies leading o revolutionary therapeutic interventions [1… (More)
DOI: 10.1016/j.leukres.2011.05.008