Chromosomal translocation involving the immunoglobulin kappa-chain and heavy-chain loci in a child with chronic lymphocytic leukemia.

@article{Sonnier1983ChromosomalTI,
  title={Chromosomal translocation involving the immunoglobulin kappa-chain and heavy-chain loci in a child with chronic lymphocytic leukemia.},
  author={J A Sonnier and George R. Buchanan and Patricia N. Howard-Peebles and Joe Rutledge and R. G. Smith},
  journal={The New England journal of medicine},
  year={1983},
  volume={309 10},
  pages={590-4}
}
Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type. Karyotyping of the abnormal cells revealed an unusual translocation [t(2;14) (p13;q32)], with break points at or near the kappa-light-chain and heavy-chain gene loci. Translocations involving the… CONTINUE READING

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