Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas.

@article{Tokino1987ChromosomalTA,
  title={Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas.},
  author={Takashi Tokino and Shin‐ichi Fukushige and Takaaki Nakamura and Takashi Nagaya and Tomoaki Murotsu and Kiyoto Shiga and Naoto Aoki and Kenichi Matsubara},
  journal={Journal of virology},
  year={1987},
  volume={61 12},
  pages={3848-54}
}
Integrated hepatitis B virus (HBV) DNA is found in hepatocellular carcinomas which develop in HBV carriers. Presented here are the results of analyses of four integrants that show chromosomal rearrangements associated with the integrated HBV DNA. Two clones (p4 and C15) were found to have large inverted repeating structures, each consisting of HBV genome along with flanking cellular sequences. The structure must have arisen by duplication of the primary integrant, including the flanking… CONTINUE READING