Chromosomal tetA(L) gene of Bacillus subtilis: regulation of expression and physiology of a tetA(L) deletion strain.

@article{Cheng1996ChromosomalTG,
  title={Chromosomal tetA(L) gene of Bacillus subtilis: regulation of expression and physiology of a tetA(L) deletion strain.},
  author={J. G. Cheng and Arthur A. Guffanti and Wei Wang and Terry Ann Krulwich and David H. Bechhofer},
  journal={Journal of bacteriology},
  year={1996},
  volume={178 10},
  pages={
          2853-60
        }
}
Deletion of the tetA(L) chromosomal region of Bacillus subtilis in a strain designated JC112 increased the strain's sensitivity to low tetracycline concentrations. It also resulted in phenotypic changes that correlate with the previously found role of TetA(L) in mediating electrogenic NA+/H+ antiport. Growth of JC112 was impaired relative to that of the wild type at both pH 7.0 and 8.3; Na(+)- and K(+)-dependent pH homeostases were impaired at alkaline pH. The phenotype of JC112 was… CONTINUE READING

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