Chromosomal receptor for a vitamin D metabolite.

  title={Chromosomal receptor for a vitamin D metabolite.},
  author={Mark R. Haussler and Anthony W. Norman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={62 1},
Evidence has been presented for the existence of an acidic protein(s) or protein portion of a more complex molecule which has a high affinity for binding noncovalently a biologically active metabolite of vitamin D. This molecule could be solubilized from the residual chromatin via treatment with either 0.3 M KCl or high pH and has been purified 167-fold over the crude mucosa homogenate. Characterization of the still crude receptor fraction showed that it contains significant amounts of RNA and… CONTINUE READING