Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.

@article{Costa1992ChromosomalPO,
  title={Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.},
  author={T E Costa and Heikyung Suh and Michel C. Nussenzweig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 6},
  pages={2205-8}
}
Formation of a complete immunoglobulin heavy-chain transcription unit involves the ordered rearrangement of variable (V), diversity (D), and joining (J) region gene segments. In antibody-producing cells, this process is regulated such that only one of two antibody genes is expressed. Experiments with transgenic mice suggest that this mechanism, known as allelic exclusion, is mediated through the membrane-bound form of the immunoglobulin heavy chain. However, in all transgenic lines produced to… CONTINUE READING

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