Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

@article{Hilbert1991ChromosomalMO,
  title={Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats},
  author={Pascale Hilbert and Klaus Lindpaintner and Jacques S. Beckmann and Tadao Serikawa and Florent Soubrier and Christopher Dubay and Paulyn Cartwright and B{\'e}atrice De Gouyon and C{\'e}cile Julier and Sugata Takahasi and Madeleine Vincent and Dr. T.M. Ganten and Michel Georges and G. M. Lathrop},
  journal={Nature},
  year={1991},
  volume={353},
  pages={521-529}
}
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure1–7. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood… CONTINUE READING
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