Chromosomal mapping of the αMHC-MerCreMer transgene in mice reveals a large genomic deletion

@article{Harkins2016ChromosomalMO,
  title={Chromosomal mapping of the αMHC-MerCreMer transgene in mice reveals a large genomic deletion},
  author={Stephanie Harkins and J. Lindsay Whitton},
  journal={Transgenic Research},
  year={2016},
  volume={25},
  pages={639-648}
}
Transgenic mice expressing a tamoxifen-inducible Cre recombinase specifically in cardiomyocytes were generated in 2001 and are in widespread use, having been employed in >150 published studies. However, several groups recently have reported that tamoxifen administration to these mice can have off-target effects that include cardiac dysfunction, fibrosis… CONTINUE READING