Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule

@article{Gelegen2010ChromosomalMO,
  title={Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule},
  author={Cigdem Gelegen and Eneda Pjetri and Iain C. Campbell and David A. Collier and Martien J. Kas},
  journal={European Neuropsychopharmacology},
  year={2010},
  volume={20},
  pages={317-326}
}
Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains derived from C57BL/6J and A/J strains was exposed to a scheduled feeding paradigm and to voluntary running wheel (RW) access. Here, we showed that A/J chromosomes 4, 12 and 13 contribute to the development of a disrupted RW activity in response to… CONTINUE READING

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