Chromosomal location of human T-cell receptor gene Ti beta.

Abstract

A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

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@article{Barker1984ChromosomalLO, title={Chromosomal location of human T-cell receptor gene Ti beta.}, author={Peter E. Barker and F. H. Ruddle and Hans Dieter Royer and Oreste Acuto and E. L. Reinherz}, journal={Science}, year={1984}, volume={226 4672}, pages={348-9} }