Chromosomal location of human T-cell receptor gene Ti beta.


A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.


Citations per Year

719 Citations

Semantic Scholar estimates that this publication has 719 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Barker1984ChromosomalLO, title={Chromosomal location of human T-cell receptor gene Ti beta.}, author={Peter E. Barker and F. H. Ruddle and Hans Dieter Royer and Oreste Acuto and E. L. Reinherz}, journal={Science}, year={1984}, volume={226 4672}, pages={348-9} }