Chromosomal localization of three human genes coding for A15, L6, and S5.7(TAPA1): all members of the transmembrane 4 superfamily of proteins

  title={Chromosomal localization of three human genes coding for A15, L6, and S5.7(TAPA1): all members of the transmembrane 4 superfamily of proteins},
  author={Kimmo Virtaneva and Nobuhiko Emi and John S. Marken and Alejandro Aruffo and Carol A. Jones and N. K. Spurr and Jim P. Schr{\"o}der},
The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome, and myotonic dystrophy. The L6 antigen is mainly expressed in lung, breast, colon, ovarian carcinomas, and healthy epithelial tissue in humans. The… 
Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82
The gene structure of the leukocyte-expressed members of the transmembrane 4 superfamily are strikingly conserved and, moreover, the chromosomal localization of the genes encoding mouse CD53 and CD37 show clear evidence that these two member of the TM4SF arose divergently as a result of an ancient chromosomal duplica-like structure.
Role of Transmembrane 4 L Six Family 1 in the Development and Progression of Cancer
The many functions of TM4SF1 in malignant tumors are reviewed with the aim to understand the interaction between its expression and the biological behaviors of cancer and to supply a basis for exploring new therapeutic targets.
CD81 is a candidate tumor suppressor gene in human gastric cancer
It is concluded that epigenetic inactivation of CD81 is a common feature of gastric tumors and that this inactivation may render growth and survival advantages to the tumor cells, at least partially through p38 signaling.
Isolation and characterisation of mesenchymal stem cells
Results suggest STEAP1 and STEAP2 may be novel MSC markers in murine and in human cells and further work is needed to elucidate their role in MSCs and to establish their usefulness as potential cell-specific markers.
Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge
Network visualization revealed the capability of microglia to exhibit transcriptome dysregulation in response to immune challenge still after resolution of sickness symptoms, albeit lower than that observed in macrophages.


The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes
The CD37, CD53, and R2 leukocyte surface antigens genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively.
Cloning and expression of the tumor-associated antigen L6.
The expression cloning of a cDNA encoding the L6 antigen is described and it is shown that COS cells transfected with this cDNA direct the expression of an approximately 24-kDa surface protein that reacts with the two anti-L6 monoclonal antibodies available.
Genomic organization and chromosomal localization of the TAPA-1 gene.
The organization of the TAPA-1 gene and the projection of the exon boundaries on the proposed protein structure are presented and the genes were found to be part of a conserved syntenic group in mouse chromosome 7 and the short arm of human chromosome 11.
Human ferritin genes: chromosomal assignments and polymorphisms.
The possibility that gene-family probes that hybridize to many discrete members of dispersed gene families could be used in conjunction with pulsed- or inverted-field gels to screen a large number of specific genomic regions for microdeletions is discussed.
Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents.
Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human, and rat (CD53).
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.
Analysis of the deduced amino acid sequence indicated that the TAPA-1 protein is highly hydrophobic and that it contains four putative transmembrane domains and a potential N-myristoylation site, which may play an important role in the regulation of lymphoma cell growth.
Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily
A computer-aided comparison showed a marked similarity to several other membrane proteins: CD9, CD37, CD53, TAPA-1, Sm23, CO-029, and ME491/CD63.
Molecular cloning of the CD9 antigen. A new family of cell surface proteins.
Sequence and structural comparisons showed extensive similarity of the CD9 antigen with a 237-amino acid molecule described previously as the human melanoma-associated antigen ME491 and a Schistosoma mansoni membrane protein of 218 amino acids, which identify a new family of cell-surface proteins.
Regional localization of the human transferrin receptor gene to 3q26.2----qter.
The chromosomal locus of the receptor gene was determined by in situ hybridization to 3q26.2----qter, a region of chromosome 3 that appears to be involved in metal transport and that is subject to nonrandom structural rearrangements associated with neoplasia.