Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

@article{Stapleton1993ChromosomalLO,
  title={Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9},
  author={Paula Stapleton and Andreas Weith and Pavel Urb{\'a}nek and Zbyněk Kozm{\'i}k and Meinrad Busslinger},
  journal={Nature Genetics},
  year={1993},
  volume={3},
  pages={292-298}
}
In the human paired box-containing (PAX) gene family, only two members, PAX-3 and PAX-6, which are associated with Waardenburg's syndrome and aniridia, respectively have been mapped to human chromosomes. We have now isolated cosmids for six additional human PAX genes (PAX-1,-2,-5,-7,-8,-9) and a polymerase chain reaction fragment for PAX-4. PAX-9 is a novel family member which is closely related in its paired domain to PAX-1. The chromosomal location of all cloned PAX genes was determined by… 

The genomic organization and the full coding region of the human PAX7 gene.

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The PAX5 gene: a linkage and mutation analysis in candidate human primary immunodeficiencies

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Evidence that there is an additional conserved region near the predicted COOH-terminus of PAX-2, PAX-5, and PAX-8 is provided and alternative splicing of a conserved 83-nucleotide segment in the 3' coding sequence of the PAX- 2 gene is described.

The PAX 3-FKHR Fusion Protein Created by the t ( 2 ; 13 ) Translocation in Alveolar Rhabdomyosarcomas Is a More Potent Transcriptional Activator than PAX 3

The PAX3-FKHR protein may function as an oncogenic transcription factor by enhanced activation of normal PAX3 target genes and was a much more potent transcriptional activator than PAX3 as determined by transient cotransfection assays using e5-CAT reporter plasmids.

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

The PAX3-FKHR protein may function as an oncogenic transcription factor by enhanced activation of normal PAX3 target genes and was a much more potent transcriptional activator than PAX3 as determined by transient cotransfection assays using e5-CAT reporter plasmids.

Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8

The PAX8 gene, a member of the human paired box gene family, was mapped by FISH to chromosome 11 in cattle and goat and to the short arm of chromosome 3 in sheep and the results indicated that PAX8 as well as interleukin beta and interLEukin alpha genes detected on the human chromosome segment HSA 2q13→q21 maintain a similar order and location in these three related species.
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Pax-8, a member of the paired box-containing gene family, was shown to be coexpressed with Pax-2 in several human kidney carcinoma cell lines and the same four mRNA variants were detected by RNase protection analysis in the mouse embryo and adult kidney, indicating evolutionary conservation of Pax-8 mRNA splicing.

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