Chromosomal localization of mouse and human neurotensin receptor genes

  title={Chromosomal localization of mouse and human neurotensin receptor genes},
  author={Patrick Laurent and Pascal Clerc and Marie Genevi{\`e}ve Mattei and Patricia Forgez and Xavier Dumont and Pascual Ferrara and Daniel Caput and William Rost{\`e}ne},
  journal={Mammalian Genome},
Neurotensin is a tridecapeptide that plays several neurotransmitter or neuromodulatory roles both in the central nervous system and in the periphery. These actions are mediated by a high-affinity receptor (Ntsr). Both rat and human cDNAs encoding high-affinity receptors have been recently cloned. The availability of Ntsr probes allowed us to localize the corresponding genes on the mouse and human chromosomes. The present data demonstrate that the Ntsr gene is assigned to the H region of the… 

Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [38]) are activated by the endogenous tridecapeptide neurotensin derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS2 receptor.

Neurotensin Receptor 1 Gene (NTSR1) Polymorphism Is Associated with Working Memory

Previous rodent studies showing that the NT deficiency impairs the working memory function were extended, and it was demonstrated that NTSR1 SNP polymorphisms were significantly associated with variance in working memory performance among healthy adults.

JPH2 is a novel susceptibility gene on chromosome 20q associated with diabetic retinopathy in a Taiwanese population

The results implicate that genetic variants of JPH2 are associated with the pathogenesis of DR, particularly in the earlier non- proliferative phase, and indicates that J PH2 is a plausible new candidate gene for DR development.

Caractérisation fonctionnelle du récepteur de type 2 de la neurotensine dans la résistance à la mort cellulaire des lymphocytes B au cours de la Leucémie Lymphoïde Chronique

La leucemie lymphoide chronique (LLC) est caracterisee par une accumulation anormale de lymphocytes B matures. Les therapies actuelles reposent sur l'utilisation d'inhibiteurs ciblant les kinases



Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor

Structure and functional expression of the cloned rat neurotensin receptor

The genes coding for phosphoenolpyruvate carboxykinase‐1 (PCK1) and neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2

Southern blot analysis on human/rodent somatic cell hybrids is utilized to map the human homologues of both of these genes, PCK1 and CHRNA4, to human chromosome 20.

Interaction between Neurotensin and Dopamine in the Brain

Neuroanatomical data accumulated during the past ten years are in favor of possible NT-DA interactions, and specific high-affinity NT binding sites have been described in both substantia nigra and the ventral tegmental area.

Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor.

  • D. GullyM. Canton A. Brouard
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
Being a potent and selective neurotensin receptor antagonist, SR 48692 may be considered as a powerful tool for investigating the role of neurotens in physiological and pathological processes.