Chromosomal localization and preliminary characterization of the human gene encoding insulin-like growth factor II

@article{PagterHolthuizen1985ChromosomalLA,
  title={Chromosomal localization and preliminary characterization of the human gene encoding insulin-like growth factor II},
  author={P. de Pagter-Holthuizen and Jo W. M. H{\"o}ppener and Mieke Jansen and A. Geurts van Kessel and Gert-Jan B. van Ommen and John S. Sussenbach},
  journal={Human Genetics},
  year={1985},
  volume={69},
  pages={170-173}
}
A cDNA probe corresponding to mRNA encoding a closely related variant of human insulin-like growth factor II (IGF-II) was used for the chromosomal assignment of the IGF-II gene. Southern blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the human IGF-II gene is located on chromosome 11. Using the same IGF-II variant probe, a cosmid was isolated which contains the human IGF-II gene. Restriction enzyme analysis revealed that the gene encoding IGF-II… CONTINUE READING
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