Chromosomal instability of murine adipose tissue-derived mesenchymal stem cells in long-term culture and development of cloned embryos.

@article{Qin2009ChromosomalIO,
  title={Chromosomal instability of murine adipose tissue-derived mesenchymal stem cells in long-term culture and development of cloned embryos.},
  author={Yiren Qin and Hong Ji and Yanguang Wu and Huiwen Liu},
  journal={Cloning and stem cells},
  year={2009},
  volume={11 3},
  pages={445-52}
}
Mice are the most commonly used laboratory animals for research, and some mouse stem cells, such as induced pluripotent stem cells, embryonic stem cells, and mesenchymal stem cells (MSCs), are also widely used in basic research. It is thus important to know if these stem cells maintain their genomic stability when cultured. Murine bone marrow-derived mesenchymal stem cells (BMSCs) appear to undergo spontaneous transformation in vitro. Murine adipose tissue-derived mesenchymal stem cells (ADSCs… CONTINUE READING
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