Chromosomal instability in rodents caused by pollution from Baikonur cosmodrome

  title={Chromosomal instability in rodents caused by pollution from Baikonur cosmodrome},
  author={Saule Zh. Kolumbayeva and Dinara Begimbetova and Tamara M. Shalakhmetova and Timur Saliev and Anna V. Lovinskaya and Benazir Zhunusbekova},
An assessment of the health status of ecosystems exposed to man-made pollution is a vital issue for many countries. Particularly it concerns the consequences of contamination caused by the activity of the space industry. Each rocket launch is accompanied by the introduction of parts of the rocket propellant into the environment. This study aims to scrutinize the effect of the components of rocket fuel on the induction of lipid peroxidation and chromosomal aberrations on rodents inhabiting the… 
Genotoxic effects of N-nitrosodimethylamine in somatic and generative cells of mice
The organ-specificity of the genotoxic effect of NDMA was revealed using the Comet assay, with the most sensitive organs to the action ofNDMA were kidneys and liver.
Chromosomal instability--mechanisms and consequences.
The Study of the Mutagenic Effect of Carbon Dioxide on Soybean line T-219 (Glycine max (l.) Merrill)
The mutagenic activity of carbon dioxide (CO2) on the mutant soybean line T-219 (Glycine max(L.) Merrill), in which the synthesis of chlorophyll depends on the allelic state of the gene, was
Possibilities for decreasing detection limits of analytical methods for determination of transformation products of unsymmetrical dimethylhydrazine in environmental samples
Most rockets of middle and heavy class launched from Kazakhstan, Russia, China and other countries still use highly toxic unsymmetrical dimethylhydrazine (UDMH) as a liquid propellant. Study of
Rocket Wastelands in Kazakhstan: Scientific Authoritarianism and the Baikonur Cosmodrome
  • Robert A. Kopack
  • Political Science
    Environmental Governance in a Populist/Authoritarian Era
  • 2020
In this article, I examine how the authoritarian control of scientific research with regard to the Russian space program and the Baikonur Cosmodrome sustains toxic geographies and an information void
Possible directions for reducing the influence of the rocket and space industry on the environment
  • V. K. Novikov, S. Novikov, V. Tatarinov
  • Computer Science
    XLIII ACADEMIC SPACE CONFERENCE: dedicated to the memory of academician S.P. Korolev and other outstanding Russian scientists – Pioneers of space exploration
  • 2019
The results of studies of the features of the influence of rocket and space activities (RSA) on the environment are presented and possible methods of detoxification of asymmetric dimethylhydrazine (ADMH) are described.
Baikonur 2.0: ‘inland-offshore’ space economies in post-Soviet Kazakhstan
ABSTRACT The global space industry brings to mind the horizons of science and technology, large rockets, and heroic astronauts. The land and infrastructure used to launch things into the cosmos,
Environmental Geopolitics and Outer Space
ABSTRACT The cultural, legal, budgetary, infrastructural, and logistical processes through which the contemporary space race unfolds have measurable environmental footprints on Earth and in outer
Modern approaches to rocket propellant disposition
The study reflects modern approaches to disposition of toxic components of liquid rocket propellant, which results in obtaining products with high added value finding practical application in the


Mutagenic activity as a parameter to assess ambient air quality for protection of the environment and human health.
Lipid peroxidation-DNA damage by malondialdehyde.
Genomic Approach for Understanding the Mutagenic and Carcinogenic Mechanisms of Heavy Metal Nickel in terms of Gene-environment Interaction.
This work confirmed the protective effect of the Nrf2 gene under oxidative stress and DNA damage induced by 20uM nickel at sub-lethal doses in terms of gene-environment interactions and attempted to identify potential nickel and NRF2-responsive targets and the relevant pathway via microarray, qRT-PCR, and pathway analysis.
Association Study of the Frequencies of Spontaneous and Induced Chromosome Aberrations in Human Lymphocytes
The frequency of spontaneous aberrations of chromosome type was reduced for homozygotes by the deletion of GSTM1 locus, especially for double homozygote by the deletions of GST M-GSTT1 genes.
Ecotoxicological Risks Associated with Land Treatment of Petrochemical Wastes. I. Residual Soil Contamination and Bioaccumulation by Cotton Rats (Sigmodon Hispidus)
This study shows that certain contaminants such as Pb and F tend to bioaccumulate in cotton rats collected from land treatment units andLand treatment was ineffective in reducing levels of these contaminants to background levels that will not pose an increase in risk to terrestrial mammals.
The metabolism of NDMA appears to be similar in humans and animals; as a result, it is considered highly likely that NDMA is carcinogenic to humans.
Damage of DNA and proteins by major lipid peroxidation products in genome stability
This review summarizes consequences of LPO products’ presence in cell, particularly 4-hydroxy-2-nonenal, in terms of genomic stability.
It is shown that bioavailability of radionuclides in the “soil-to-plant” chain and a trophic specialization of animals play key roles in determining their actual contamination levels and their total absorbed dose rates significantly reduced during the years following the Chernobyl Nuclear Power Plant accident.