Chromosomal instability in oral cancer cells.

  title={Chromosomal instability in oral cancer cells.},
  author={Shalini C Reshmi and Susanne M Gollin},
  journal={Journal of dental research},
  volume={84 2},
Chromosomal instability is a common feature of human tumors, including oral cancer. Although a tumor karyotype may remain quite stable over time, chromosomal instability can lead to 'variations on a theme' of a clonal cell population, often with each cell within a tumor possessing a different karyotype. Thus, chromosomal instability appears to be an important acquired feature of tumor cells, since propagation of such a diverse cell population may facilitate evasion of standard therapies. There… CONTINUE READING