Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences

Abstract

Formation of a totipotent blastocyst capable of implantation is one of the first major milestones in early mammalian embryogenesis, but less than half of in vitro fertilized embryos from most mammals will progress to this stage of development. Whole chromosomal abnormalities, or aneuploidy, are key determinants of whether human embryos will arrest or reach… (More)
DOI: 10.1007/s00441-015-2305-6

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