Chromosomal instability in cancer: causality and interdependence.

  title={Chromosomal instability in cancer: causality and interdependence.},
  author={Ashok R. Venkitaraman},
  journal={Cell cycle},
  volume={6 19},
Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated. 

From This Paper

Topics from this paper.


Publications citing this paper.

Similar Papers

Loading similar papers…