Chromosomal instability in cancer: causality and interdependence.

@article{Venkitaraman2007ChromosomalII,
  title={Chromosomal instability in cancer: causality and interdependence.},
  author={Ashok R. Venkitaraman},
  journal={Cell cycle},
  year={2007},
  volume={6 19},
  pages={2341-3}
}
Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated. 

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