Chromosomal instability and delayed apoptosis in long-term T-lymphocyte cultures irradiated with carbon ions and x rays.

@article{HofmanHther2006ChromosomalIA,
  title={Chromosomal instability and delayed apoptosis in long-term T-lymphocyte cultures irradiated with carbon ions and x rays.},
  author={Hana Hofman-H{\"u}ther and Hannah Peuckert and Sylvia Ritter and Patricia Virsik-K{\"o}pp},
  journal={Radiation research},
  year={2006},
  volume={166 6},
  pages={858-69}
}
In this study, we examined genomic instability induced by 250 kV X rays and 100 MeV/nucleon carbon ions in long-term lymphocyte cultures from two healthy donors. Two biological end points, delayed apoptosis and chromosomal instability, were studied in descendants of cells irradiated with three different doses of the particular radiation up to 22 population doublings. The delayed apoptosis showed no clear dependence on radiation dose, culture time or radiation quality. A persistent significant… CONTINUE READING