Chromosomal instability and cytoskeletal defects in oral cancer cells.

  title={Chromosomal instability and cytoskeletal defects in oral cancer cells.},
  author={William S. Saunders and Michele I. Shuster and Xuhui Huang and Burhan M. Gharaibeh and Akon H Enyenihi and Iver Petersen and Susanne M Gollin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 1},
Oral squamous cell carcinomas are characterized by complex, often near-triploid karyotypes with structural and numerical variations superimposed on the initial clonal chromosomal alterations. We used immunohistochemistry combined with classical cytogenetic analysis and spectral karyotyping to investigate the chromosomal segregation defects in cultured oral squamous cell carcinoma cells. During division, these cells frequently exhibit lagging chromosomes at both metaphase and anaphase… CONTINUE READING