Chromosomal insertion and excision of a 30 kb unstable genetic element is responsible for phase variation of lipopolysaccharide and other virulence determinants in Legionella pneumophila.

@article{Lneberg2001ChromosomalIA,
  title={Chromosomal insertion and excision of a 30 kb unstable genetic element is responsible for phase variation of lipopolysaccharide and other virulence determinants in Legionella pneumophila.},
  author={Edeltraud L{\"u}neberg and Bernd Mayer and Neda Daryab and Oliver Kooistra and Ulrich Zaehringer and Manfred Rohde and John P. Swanson and Matthias Frosch},
  journal={Molecular microbiology},
  year={2001},
  volume={39 5},
  pages={
          1259-71
        }
}
We recently described the phase-variable expression of a virulence-associated lipopolysaccharide (LPS) epitope in Legionella pneumophila. In this study, the molecular mechanism for phase variation was investigated. We identified a 30 kb unstable genetic element as the molecular origin for LPS phase variation. Thirty putative genes were encoded on the 30 kb sequence, organized in two putative opposite transcription units. Some of the open reading frames (ORFs) shared homologies with… CONTINUE READING
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