Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization.

@article{Bastian1998ChromosomalGA,
  title={Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization.},
  author={Boris C. Bastian and Philip E. Leboit and H. Hamm and Eva Bettina Br{\"o}cker and Daniel Pinkel},
  journal={Cancer research},
  year={1998},
  volume={58 10},
  pages={2170-5}
}
The analysis of genetic changes in primary cutaneous melanoma has been limited by the need for fixation for diagnostic purposes. However, comparative genomic hybridization is able to analyze such specimens. We have applied comparative genomic hybridization to 32 primary melanomas to discover and map genomic regions with aberrant DNA copy numbers. The analysis was performed on native, nonamplified DNA extracted from manually dissected tumor sections. Loss of chromosome 9 was detected in 81% of… CONTINUE READING
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