Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.

@article{Thomas2014ChromosomalGA,
  title={Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.},
  author={Lorenz K Thomas and Justo Lorenzo Bermejo and Svetlana Vinokurova and Katrin Jensen and Mariska Bierkens and Renske D. M. Steenbergen and Marion Bergmann and Magnus von Knebel Doeberitz and Miriam Reuschenbach},
  journal={European journal of cancer},
  year={2014},
  volume={50 1},
  pages={85-98}
}
BACKGROUND Overexpression of the human papillomavirus (HPV) oncogenes E6 and E7 is necessary for the development of distinct lower genital tract cancers. However, secondary cellular genomic alterations are mandatory to promote progression of HPV-induced premalignant stages. We aimed at identifying the chromosomal regions most frequently gained and lost and the disease stage at which the latter occurs. These regions might be relevant for carcinogenesis and could serve as diagnostic markers to… CONTINUE READING
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