Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens

@article{Fahmy2004ChromosomalGA,
  title={Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens},
  author={Mona Fahmy and Marek Skacel and Terry L Gramlich and Jennifer Ann Brainard and Thomas William Rice and John R. Goldblum and Jason Connor and Graham R Casey and Mona S. Legator and Raymond R. Tubbs and Gary W. Falk},
  journal={Modern Pathology},
  year={2004},
  volume={17},
  pages={588-596}
}
Endoscopic brush cytology is a promising surveillance technique for Barrett's esophagus. Ancillary markers are sought to increase the sensitivity of cytology and allow identification of patients at increased risk for disease progression. To determine if there are specific genetic changes in Barrett's esophagus with associated high-grade dysplasia/intramucosal adenocarcinoma compared to those without dysplasia, we performed fluorescence in situ hybridization (FISH) on cytologic specimens using… CONTINUE READING