Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells

@inproceedings{Hasegawa2013ChromosomalGP,
  title={Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells},
  author={Keisuke Hasegawa and Sung Jin Ryu and Petr Kal{\'a}b},
  booktitle={The Journal of cell biology},
  year={2013}
}
Many mitotic factors were shown to be activated by Ran guanosine triphosphatase. Previous studies in Xenopus laevis egg extracts and in highly proliferative cells showed that mitotic chromosomes were surrounded by steep Ran guanosine triphosphate (GTP) concentration gradients, indicating that RanGTP-activated factors promote spindle assembly around chromosomes. However, the mitotic role of Ran in normal differentiated cells is not known. In this paper, we show that although the steep mitotic… CONTINUE READING

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