Chromosomal fragile site FRA16D and DNA instability in cancer.

  title={Chromosomal fragile site FRA16D and DNA instability in cancer.},
  author={Marie E. Mangelsdorf and Karin Ried and Erica Woollatt and Sonia Dayan and Helen Eyre and Merran Finnis and Lynne Hobson and Jeffrey Nancarrow and Deon J Venter and Elizabeth G. Baker and Robert I. Richards},
  journal={Cancer research},
  volume={60 6},
It has been proposed that common aphidicolin-inducible fragile sites, in general, predispose to specific chromosomal breakage associated with deletion, amplification, and/or translocation in certain forms of cancer. Although this appears to be the case for the fragile site FRA3B and may be the case for FRA7G, it is not yet clear whether this association is a general property of this class of fragile site. The major aim of the present study was to determine whether the FRA16D chromosomal fragile… CONTINUE READING