Chromosomal directionality of DNA mismatch repair in Escherichia coli.

  title={Chromosomal directionality of DNA mismatch repair in Escherichia coli.},
  author={A. M. Mahedi Hasan and David R F Leach},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 30},
Defects in DNA mismatch repair (MMR) result in elevated mutagenesis and in cancer predisposition. This disease burden arises because MMR is required to correct errors made in the copying of DNA. MMR is bidirectional at the level of DNA strand polarity as it operates equally well in the 5' to 3' and the 3' to 5' directions. However, the directionality of MMR with respect to the chromosome, which comprises parental DNA strands of opposite polarity, has been unknown. Here, we show that MMR in… CONTINUE READING
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