Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways.

@article{Lindroos2006ChromosomalAO,
  title={Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways.},
  author={Hanna Betts Lindroos and Lena Str{\"o}m and Takehiko Itoh and Yuki Katou and Katsuhiko Shirahige and Camilla Sj{\"o}gren},
  journal={Molecular cell},
  year={2006},
  volume={22 6},
  pages={755-67}
}
The SMC protein complexes safeguard genomic integrity through their functions in chromosome segregation and repair. The chromosomal localization of the budding yeast Smc5/6 complex determined here reveals that the complex works specifically on the duplicated genome in differently regulated pathways. The first controls the association to centromeres and chromosome arms in unchallenged cells, the second regulates the association to DNA breaks, and the third directs the complex to the chromosome… CONTINUE READING
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