Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.

@article{Mbikay1995ChromosomalAO,
  title={Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.},
  author={Majambu Mbikay and Nabil G Seidah and Michel Chr{\'e}tien and Elizabeth M. Simpson},
  journal={Genomics},
  year={1995},
  volume={26 1},
  pages={123-9}
}
The genes for three subtilisin/kexin-like proprotein convertases, PC4, PC5, and PACE4, were mapped in the mouse by RFLP analysis of a DNA panel from a (C57BL/6JEi x SPRET/Ei)F1 x SPRET/Ei backcross. The chromosomal locations of the human homologs were determined by Southern blot analysis of a DNA panel from human-rodent somatic cell hybrids, most of which contained a single human chromosome each. The gene for PC4 (Pcsk4 locus) mapped to mouse chromosome 10, close to the Adn (adipsin, a serine… CONTINUE READING