Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus

@inproceedings{Ranade2016ChromosomalAI,
  title={Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus},
  author={Devika Ranade and Shivsmriti Koul and Joyce Thompson and Kumar Brajesh Prasad and Kundan Sengupta},
  booktitle={Chromosoma},
  year={2016}
}
Chromosome territories assume non-random positions in the interphase nucleus with gene-rich chromosomes localized toward the nuclear interior and gene-poor chromosome territories toward the nuclear periphery. Lamins are intermediate filament proteins of the inner nuclear membrane required for the maintenance of nuclear structure and function. Here, we show using whole-genome expression profiling that Lamin A/C or Lamin B2 depletion in an otherwise diploid colorectal cancer cell line (DLD1… CONTINUE READING

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