Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds

  title={Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds},
  author={L. Governini and C. Guerranti and V. De Leo and L. Boschi and A. Luddi and M. Gori and R. Orvieto and P. Piomboni},
  • L. Governini, C. Guerranti, +5 authors P. Piomboni
  • Published 2015
  • Biology, Medicine
  • Andrologia
  • This study investigated chromosomal aneuploidies and DNA damage in spermatozoa from male patients contaminated by perfluorinated compounds (PFCs) in whole blood and seminal plasma. Sperm aneuploidy and diploidy rate for chromosomes 18, X and Y were evaluated by FISH; sperm DNA fragmentation was assessed by terminal deoxynucleotidyl transferase‐mediated dUTP nick end‐labelling technique coupled to flow cytometry. Our results indicated that PFC contamination was present in 58% of subjects… CONTINUE READING
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