Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds

@article{Governini2015ChromosomalAA,
  title={Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds},
  author={L. Governini and C. Guerranti and V. De Leo and L. Boschi and A. Luddi and M. Gori and R. Orvieto and P. Piomboni},
  journal={Andrologia},
  year={2015},
  volume={47}
}
  • L. Governini, C. Guerranti, +5 authors P. Piomboni
  • Published 2015
  • Biology, Medicine
  • Andrologia
  • This study investigated chromosomal aneuploidies and DNA damage in spermatozoa from male patients contaminated by perfluorinated compounds (PFCs) in whole blood and seminal plasma. Sperm aneuploidy and diploidy rate for chromosomes 18, X and Y were evaluated by FISH; sperm DNA fragmentation was assessed by terminal deoxynucleotidyl transferase‐mediated dUTP nick end‐labelling technique coupled to flow cytometry. Our results indicated that PFC contamination was present in 58% of subjects… CONTINUE READING
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    References

    SHOWING 1-10 OF 37 REFERENCES
    Nuclear staining identifies two populations of human sperm with different DNA fragmentation extent and relationship with semen parameters.
    • 64
    • PDF
    Biological and clinical significance of DNA damage in the male germ line.
    • 331
    Reliability of aneuploidy estimates in human sperm: Results of fluorescence in situ hybridization studies using two different scoring criteria
    • 91
    Effects of environmental and occupational pesticide exposure on human sperm: a systematic review.
    • M. Perry
    • Biology, Medicine
    • Human reproduction update
    • 2008
    • 121
    • PDF
    Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity.
    • 140
    • PDF
    Human Exposure to Endocrine Disrupters and Semen Quality
    • 164
    Do Perfluoroalkyl Compounds Impair Human Semen Quality?
    • 277
    • Highly Influential
    • PDF
    The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity
    • 26