Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds

@article{Governini2015ChromosomalAA,
  title={Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds},
  author={Laura Governini and Cristiana Guerranti and Vincenzo de Leo and L Boschi and Alice Luddi and Martina Gori and Raoul Orvieto and Paola Piomboni},
  journal={Andrologia},
  year={2015},
  volume={47}
}
This study investigated chromosomal aneuploidies and DNA damage in spermatozoa from male patients contaminated by perfluorinated compounds (PFCs) in whole blood and seminal plasma. Sperm aneuploidy and diploidy rate for chromosomes 18, X and Y were evaluated by FISH; sperm DNA fragmentation was assessed by terminal deoxynucleotidyl transferase‐mediated dUTP nick end‐labelling technique coupled to flow cytometry. Our results indicated that PFC contamination was present in 58% of subjects… 

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