Chromosomal analysis in Ewing sarcoma.


Two cases of Ewing sarcoma were karyotyped by using a fluorodeoxyuridine synchronisation procedure on short term cultures of fresh tumour material. This procedure enables rapid cytogenetic analysis of such material. Both showed relatively simple karyotypes, 48,XX, +2, +7,t(11;22)(q24;q12), ?dup(12)(q21----q24) and 47,XX,i(1q),t(11;22)(q24;q12). These results further support this translocation between chromosomes 11 and 22 as a specific marker for Ewing sarcoma. Cytogenetic studies in such cases are an important adjunct to histological studies and in some cases may contribute to the resolution of the diagnosis.

Cite this paper

@article{Callen1987ChromosomalAI, title={Chromosomal analysis in Ewing sarcoma.}, author={David Frederick Callen and Ron D Smith and Anthony J. Bourne}, journal={Pathology}, year={1987}, volume={19 1}, pages={64-6} }