Chromosomal alterations in the clonal evolution to the metastatic stage ofquamous cell carcinomas of the lung

@article{Petersen2000ChromosomalAI,
  title={Chromosomal alterations in the clonal evolution to the metastatic stage ofquamous cell carcinomas of the lung},
  author={Simone Petersen and M Aninat-Meyer and Karsten Schl{\"u}ns and Klaus Gellert and Manfred Dietel and Iver Petersen},
  journal={British Journal of Cancer},
  year={2000},
  volume={82},
  pages={65 - 73}
}
Comparative genomic hybridization (CGH) was applied to squamous cellcarcinomas (SCC) of the lung to define chromosomal imbalances that are associated with the metastatic phenotype. In total, 64 lung SCC from 50 patients were investigated, 25 each with or without evidence of metastasis formation. The chromosomal imbalances summarized by a CGH histogram of the 50 cases revealed deletions most frequently on chromosomes 1p21–p31, 2q34–q36, 3p, 4p, 4q, 5q, 6q14–q24, 8p, 9p, 10q, 11p12–p14, 13q13… CONTINUE READING

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