Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers.

  title={Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers.},
  author={Montserrat S{\'a}nchez-C{\'e}spedes and Steven A. Ahrendt and Steven Piantadosi and Rafael Rosell and Maria Monzo and Li Wu and William H Westra and Steven C. Yang and Jin Jen and David Sidransky},
  journal={Cancer research},
  volume={61 4},
The etiology of lung tumors arising in nonsmokers remains unclear. Although mutations in the K-ras and p53 genes have been reported to be significantly higher in smoking-related lung carcinomas, in the present study we performed a more comprehensive analysis in search of additional genetic changes between lung adenocarcinoma from tobacco- and non-tobacco-exposed patients. We selected a matched cohort of 18 lifetime nonsmoking and 27 smoking patients diagnosed with primary adenocarcinoma of the… CONTINUE READING


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Mutation of thep53 gene is associated with alcohol and cigarette smoking in non-small cell lung cancer

  • S. A. Ahrendt, J. T. Chow, +5 authors D. Sidransky
  • Cancer Res.,
  • 2000
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