Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer.

@article{Knsel2004ChromosomalAD,
  title={Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer.},
  author={Thomas Kn{\"o}sel and Karsten Schl{\"u}ns and Ulrike Stein and Holger Schwabe and Peter M. Schlag and Manfred Dietel and Iver Petersen},
  journal={Neoplasia},
  year={2004},
  volume={6 1},
  pages={23-8}
}
Comparative genomic hybridization (CGH) was used to screen colorectal carcinomas for chromosomal aberrations that are associated with metastatic phenotype. In total, 63 tumor specimens from 40 patients were investigated, comprising 30 primary tumors, 22 systemic metastases (12 liver, 6 brain, and 4 abdominal wall metastases) and 11 lymph node tumors. Using statistical analysis and histograms to evaluate the chromosomal imbalances, overrepresentations were detected most frequently at 20q11.2… CONTINUE READING
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