Chromosomal abnormalities in leiomyosarcomas.

  title={Chromosomal abnormalities in leiomyosarcomas.},
  author={Chandrika Sreekantaiah and John A Davis and Avery A. Sandberg},
  journal={The American journal of pathology},
  volume={142 1},
Thirty-eight tumors from 30 patients diagnosed as leiomyosarcoma were cytogenetically assessed after short term culture. The specimens were obtained from the retroperitoneum, gastrointestinal tract, and extremities. Chromosomal abnormalities were present in 18 tumors from 13 patients; 15 tumors had clonal changes, whereas 3 tumors had numerous nonclonal changes. Ten tumors from 10 patients had normal karyotypes and no results were obtained in 10 other tumors from 7 patients. Of the tumors with… CONTINUE READING