Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821.

@article{Raimondi1999ChromosomalAI,
  title={Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821.},
  author={Susana C. Raimondi and Myron N. Chang and Yadddanapudi Ravindranath and Frederick G. Behm and M. Victoria Gresik and C. Philip Steuber and Howard J Weinstein and A J Carroll},
  journal={Blood},
  year={1999},
  volume={94 11},
  pages={3707-16}
}
We determined the type and frequency of chromosomal aberrations in leukemic cells of 478 children diagnosed with acute myeloid leukemia and enrolled in the Pediatric Oncology Group study 8821. Of the 478 cases, 109 (22.8%) had normal karyotypes. Chromosomal abnormalities of 280 patients (58.6%) were classified into subgroups: 11q23 abnormalities (n = 88, 18.4%), t(8;21) (n = 56, 11.7%), t(15;17) (n = 55, 11.5%), inv(16)/t(16;16) (n = 28, 5.9%), trisomy 8 alone (n = 10, 2.1%), monosomy 7 (n = 9… CONTINUE READING

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