Chromosomal abnormalities and birth defects among couples with colchicine treated familial Mediterranean fever.


OBJECTIVE To determine whether colchicine prescribed for familial Mediterranean fever is teratogenic. STUDY DESIGN Reproductive histories were analyzed from 326 couples referred for prenatal diagnosis because 1 partner was affected. Numbers of chromosomal abnormalities and birth defects were compared with numbers expected from published rates. RESULTS… (More)