Chromosomal aberrations in humans induced by urban air pollution: influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2.

@article{Knudsen1999ChromosomalAI,
  title={Chromosomal aberrations in humans induced by urban air pollution: influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2.},
  author={Lisbeth Ehlert Knudsen and Hannu Norppa and Michael O. Gamborg and Per Sabro Nielsen and Henrik Okkels and Helle Soll-Johanning and Edith Raffn and Hilkka J{\"a}rventaus and Herman Autrup},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1999},
  volume={8 4 Pt 1},
  pages={303-10}
}
We have studied the influence of individual susceptibility factors on the genotoxic effects of urban air pollution in 106 nonsmoking bus drivers and 101 postal workers in the Copenhagen metropolitan area. We used the frequency of chromosomal aberrations in peripheral blood lymphocytes as a biomarker of genotoxic damage and dimethylsulfate-induced unscheduled DNA synthesis in mononuclear WBCs, the glutathione S-transferase M1 (GSTM1) genotype, and the N-acetyltransferase 2 (NAT2) genotype as… CONTINUE READING