Chromosomal aberrations in esophageal squamous cell carcinoma among Chinese: gain of 12p predicts poor prognosis after surgery.

@article{Kwong2004ChromosomalAI,
  title={Chromosomal aberrations in esophageal squamous cell carcinoma among Chinese: gain of 12p predicts poor prognosis after surgery.},
  author={Dora Lai-wan Kwong and Alfred King-Yin. Lam and Xy Guan and Simon Law and Amy Tai and John Wong and Jonathan Shun-Tong Sham},
  journal={Human pathology},
  year={2004},
  volume={35 3},
  pages={309-16}
}
Sixty primary esophageal squamous cell carcinomas (ESCCs) were evaluated for cytogenetic changes by comparative genomic hybridization (CGH). Recurrent chromosomal aberrations were correlated with stage and clinical outcome after esophagectomy to identify cytogenetic changes that are of prognostic significance. Chromosomal aberrations were found in 52 (86.7%) cases. The most frequently detected chromosomal gains involved 3q (67.3%), 8q (57.7%), 5p (51.9%), 7q (28.8%), 15q (28.8%), 20p (21.2… CONTINUE READING

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