Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

@article{Bonassi2008ChromosomalAF,
  title={Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries},
  author={S. Bonassi and H. Norppa and M. Ceppi and U. Str{\"o}mberg and R. Vermeulen and A. Znaor and A. Cebulska-Wasilewska and E. Fabianova and A. Fucic and S. Gundy and I. Hansteen and L. Knudsen and J. Lazutka and P. Rossner and R. Sram and P. Boffetta},
  journal={Carcinogenesis},
  year={2008},
  volume={29},
  pages={1178 - 1183}
}
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent… Expand
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