Chromosomal Breakpoint Reuse in Genome Sequence Rearrangement

  title={Chromosomal Breakpoint Reuse in Genome Sequence Rearrangement},
  author={David Sankoff and Phil Trinh},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={12 6},
In order to apply gene-order rearrangement algorithms to the comparison of genome sequences, Pevzner and Tesler bypass gene finding and ortholog identification and use the order of homologous blocks of unannotated sequence as input. The method excludes blocks shorter than a threshold length. Here we investigate possible biases introduced by eliminating short blocks, focusing on the notion of breakpoint reuse introduced by these authors. Analytic and simulation methods show that reuse is very… CONTINUE READING
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