Chromogranins A and B as Regulators of Vesicle Cargo and Exocytosis

  title={Chromogranins A and B as Regulators of Vesicle Cargo and Exocytosis},
  author={Jos{\'e} David Machado and J{\'e}sica D{\'i}az-Vera and Natalia Dominguez and Carmen M. {\'A}lvarez and Marta Romano Pardo and Ricardo Borges},
  journal={Cellular and Molecular Neurobiology},
Chromogranins (Cgs) are acidic proteins that have been implicated in several physiological processes such as vesicle sorting, the production of bioactive peptides and the accumulation of soluble species inside large dense core vesicles (LDCV). They constitute the main protein component in the vesicular matrix of LDCV. This latter characteristic of Cgs accounts for the ability of vesicles to concentrate catecholamines and Ca2+. It is likely that Cgs are behind the delay in the neurotransmitter… CONTINUE READING


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