Chromogranin A protects vessels against tumor necrosis factor alpha-induced vascular leakage.

@article{Ferrero2004ChromograninAP,
  title={Chromogranin A protects vessels against tumor necrosis factor alpha-induced vascular leakage.},
  author={Elisabetta Ferrero and Silvia Scabini and Elena Magni and Chiara Foglieni and Daniela Belloni and Barbara Colombo and Flavio Curnis and Antonello Villa and Maria Elena Ferrero and Angelo Corti},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 3},
  pages={554-6}
}
Elevated levels of circulating chromogranin A (CgA), a protein stored in the secretory granules of many neuroendocrine cells and neurons, have been detected in the blood of patients with neuroendocrine tumors or heart failure. The pathophysiological role of increased secretion of CgA is unknown. Using mice bearing subcutaneous tumors genetically engineered to secrete CgA in circulation, we have found that increased blood levels of this protein prevent vascular leakage induced by tumor necrosis… CONTINUE READING

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