Chromogranin A is an autoantigen in type 1 diabetes

  title={Chromogranin A is an autoantigen in type 1 diabetes},
  author={Brian D Stadinski and Thomas Delong and Nichole A Reisdorph and Richard Reisdorph and Roger L. Powell and Michael G. Armstrong and Jon D Piganelli and Gene Barbour and Brenda Bradley and Frances Crawford and Philippa Marrack and Sushil K Mahata and John W. Kappler and Kathryn Haskins},
  journal={Nature Immunology},
Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases, but the antigens that stimulate their responses have been difficult to identify and in most cases are not well defined. In the nonobese diabetic (NOD) mouse model of type 1 diabetes, we have identified the peptide WE14 from chromogranin A (ChgA) as the antigen for highly diabetogenic CD4+ T cell clones. Peptide truncation and extension analysis shows that WE14 bound to the NOD mouse major histocompatibility… CONTINUE READING
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